The Wickersham House or Wickersham State Historic Site is a historic house at 213 7th Street in the Chicken Ridge area of Juneau, Alaska. It is a historic house museum operated by the state of Alaska, memorializing the life of James Wickersham (1857-1939), an influential political leader in Alaska in the early 20th century. The house, a 2-1/2 story frame structure, was built in 1899 by Frank Hammond, owner of a mining company. It was purchased by Wickersham in 1928 and remained his home until his death. The house has been operated, informally at first by Wickersham's niece, as a museum since 1958. The house was purchased by the state in 1984.

The house was listed on the National Register of Historic Places in 1976.