The Valentine Building is a historic commercial building at 202 Front Street in Juneau, Alaska. It is a prominent, irregularly-shaped two-story wood frame structure, occupying an entire five-sided city block in the historic heart of the city. It was built in phases in 1904 and 1912 by Emery Valentine, a prominent local businessman who served as mayor of Juneau for six terms. For the first half of the 20th century, the Valentine building was one of Juneau's preeminent addresses, and the building remains a fine example of Alaskan frontier architecture.

The building was listed on the National Register of Historic Places in 1985.