The Talkeetna Historic District encompasses several blocks of the historic village center of Talkeetna, Alaska. It includes buildings on Main Street, roughly between C and D Streets, along with a few buildings on C and D Streets between Front and First Streets. The village was established in 1916 as a regional construction headquarters of the Alaska Railroad, and became a home to area miners after the railroad's completion. The district includes three buildings that date to the time of the railroad construction, and another ten that were built before 1940. Most of the buildings in the district are one or two stories in height, and are either of wood frame or log construction. Notable among them is the town's first schoolhouse, now the Talkeetna Museum, and the Talkeetna Roadhouse, which was built as a residential log house in 1917 and expanded in the 1940s to serve as a roadhouse.

The district was listed on the National Register of Historic Places in 1993.